An in vitro accelerated approach based on in vivo release to assess thymopentin release from PLGA microspheres / 国际药学研究杂志

Objective To establish an accelerated method that has good correlations with in vivo release data for formulation optimization and quality control purposes of thymopentin-loaded poly (DL-lactide-co-glycolide) (PLGA) microspheres. MethodsIn vivo thymopentin release from the microspheres was studied in Sprague-Dawley rats and relevant cumulative release curves were plotted. Key factors including release medium types, ethanol concentrations, surfactant concentrations and heating temperature were investigated for the in vitro accelerated release. The conditions for accelerated release were optimized to make the accelerated release cures fit the in vivo release well. The final optimized accelerated release method was validated in other two formulations. ResultsThe final optimized accelerated release conditions were: 20% hydro-alcoholic solutions (V/V) and 0.06% Tween 80 (W/V) as the release media, gradient heating program (0-1 h at 40 °C, 1-6 h at 45 °C and 6-30 h at 50 °C) as the media heating method. After fitted with the in vivo release curves, the correlation constant r2 of (8, 13 and 28)×103 PLGA microspheres was 0.9783, 0.9886 and 0.9780, respectively. ConclusionBy introducing alcohol into the release media and applying gradient heating program, the reported accelerated method can be used in the formulation optimization and quality control of thymopentin-loaded PLGA microspheres.

Applications of viral nanoparticles in drug delivery / 国际药学研究杂志

Viral nanoparticles (VNP) are virus-based nanoparticle carriers that can be used as a building block for novel drug carriers with a variety of properties, such as enhancing their biological compatibility and ncreasing their targeting efficiencies. By the means of chemical modification and genetic engineering, researchers are able to connect various purposes molecules to the surfaces of VNP and adjust/change the protein amino acid sequence and the amino acid residues types of capsid protein, thereby mproving the drug delivering performances of capsid protein. In this paper, we review the recent advances of VNP' applications in drug delivery, and highlight the structure, surface modification methods and drug delivery features of several plant viral nanoparticles.

A review on the influences of size and surface charge of liposome on its targeted drug delivery in vivo / 药学学报

Liposomes can be cleared by the reticuloendothelial system (RES) when it is in the blood circulation in the body. And they can accumulate in the organs rich in RES in the body by passive targeting. Targeting of the liposomes is an important factor for its use as a drug carrier, and particle size as well as surface charge are important for its in vivo targeting. In this paper, studies on the influences of particle size and surface charge of the liposomes on cell binding and phagocytosis mechanism were reviewed. A comprehensive review on passive targeting effect of the particle size and surface charge of liposomes on blood, liver, spleen as well as tumor tissue was made. At last, an outlook for future research directions was made.

Anti-AIDS drugs targeting drug delivery systems: Research advances / 国际药学研究杂志

The discovery and utilization of anti-AIDS drugs therapy have not only increased lifespan, but also enhanced the quality of life of HIV infected people. However, limitations of currently available drug regimens and dosage forms often fail to effectively reduce the HIV viral load in the viral reservoirs in vivo. To overcome the drawbacks of present anti-AIDS drugs' dosage forms, engineered nanocarriers including polymeric nanoparticles, liposomes, solid lipid nanoparticles and dendrimers are developed to facilitate these drugs targeting to the HIV viral reservoirs. This article reviews recent advances in the field of targeting drug delivery systems for the treatment of AIDS.